Police were alerted at 21:43hrs on Wednesday, 31 December, to a fire at a house in Ashmead Road, Deptford.
Police officers, London Fire Brigade and London Ambulance Service all attended.
The bodies of two people – a woman aged in her 80s and a man aged in his 60s – were found inside the property.
Officers believe they know the identities of the deceased, but await formal identification and confirmation that next of kin have been informed.
An investigation has begun into the cause of the blaze, led by London Fire Brigade investigators with the support of Met officers.